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Male and female F344 rats, 10 weeks of age are used.
After 13 weeks from the commencement of treatment, organ weight, BALF inspection, histopathology for lung inflammation reaction are performed.
After 104 weeks from the commencement of treatment, carcinogenicity are estimated.
Eight weekly instillations are enough to evaluate carcinogenicity compared with vehicle control.
It is useful as a screening method to evaluate the lung injury by aspiration.
Intratracheal instillation method is rational method rather than intraperitoneal administration
for extrapolation.
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