DIMS Institute of Medical Science, Inc.

Developers of Medium-term Carcinogenesis Bioassays in the world. / Contract safety research facility.

Mission

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Safety evaluation of NANO materials

英語版 ナノ材料の安全性評価

Male and female F344 rats, 10 weeks of age are used.

After 13 weeks from the commencement of treatment, organ weight, BALF inspection, histopathology for lung inflammation reaction are performed.

After 104 weeks from the commencement of treatment, carcinogenicity are estimated.

Eight weekly instillations are enough to evaluate carcinogenicity compared with vehicle control.

It is useful as a screening method to evaluate the lung injury by aspiration.

Intratracheal instillation method is rational method rather than intraperitoneal administration

for extrapolation.

Please refer to the following website of General Procedures for Safety Test on Carbon Nanomaterials

             https://en.aist-riss.jp/assessment/6226/

Japanese

Medium-term Carcinogenesis Bioassay/Safety Assessment for Developing Products

DIMS Institute of Medical Science, Inc.

64 Goura, Nishiazai,
Azai-cho, Ichinomiya,
Aichi 491-0113, Japan

Tel: +81-586-51-1201
Fax: +81-586-51-5634

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