DIMS Institute of Medical Science, Inc.

We offer sophisticated contract research services based on a wide scholarship and experiences piled up.

Non-clinical experimental services for developmental products are carried out by our staffs learned a wide scholarship and piled up rich experiences. Contract studies are strictly conducted in compliance with GLP regulation of authorities and various guidelines.

Remarkably, unique medium-term carcinogenesis bioassay models are well assessed as capable of predicting chemical carcinogenicity in a relative short-term, and investigating a candidate substance for anti-carcinogenicity. Contract studies are conducted by fully utilizing our toxicological and pathological ability. We are looking forward to receiving your contact.

List of contract research services

We take a contracted study including medical drug, quasi-drug, agricultural chemical, food, food additive and chemical substance, etc. They are conducted in GLP- compliant facility, and reliable data are offered.
 

1.　Toxicological study

Single dose toxicity study (rats and mice)

Repeated dose toxicity study (rats and mice)

Rodent micronucleus study

Local irritation study (skin, eye)

Sensitization study (Maximization method, Adjuvant & Patch method, Buehler method)

2.　Carcinogenicity study

Medium-term skin carcinogenesis bioassay

Medium-term liver carcinogenesis bioassay

Medium-term multi-organ carcinogenesis bioassay

26-Week carcinogenicity study using rasH2 transgenic mice

 Screening test of ultra-short-term skin carcinogenesis bioassay using rasH2 transgenic mice

 Long-term carcinogenicity study (rats and mice)

3.　Genotoxicity study
     Mouse micronucleus test
     Ames test, Chromosome aberration test, etc.
       (Those tests are accepted as secondary contract test at outside laboratories.)

     Lung toxicity evaluation of chemical substances
     Pharmacological evaluation (in mouse pulmonary fibrosis model etc.)

Safety evaluation using intratracheal instillation method
 

5.  Regenerative medicine

in vivo tumorigenicity study
 

6.  Anti-tumorigenesis test
    Xenograft model using human-originated cancer cell
    Syngeneic model using mouse-originated cancer cell
    Chemical carcinogenesis model
 

7.  Preparation of histopathology specimens and histopathological evaluation